Простийпошук |
Розширенийпошук |
Покажчики
|
Професійний пошук |
Рубрикатор НБУВ |
Розподілений пошук |
Бази даних
Наукова періодика України - результати пошуку
Книжкові видання та компакт-дискиЖурнали та продовжувані виданняАвтореферати дисертаційРеферативна база данихНаукова періодика УкраїниТематичний навігаторАвторитетний файл імен осіб
 |
Для швидкої роботи та реалізації всіх функціональних можливостей пошукової системи використовуйте браузер "Mozilla Firefox" |
|
|
Повнотекстовий пошук
| Знайдено в інших БД: | Реферативна база даних (10) |
Список видань за алфавітом назв: Авторський покажчик Покажчик назв публікацій  |
Пошуковий запит: (<.>A=Horacek J$<.>) | |||
|
Загальна кількість знайдених документів : 3 Представлено документи з 1 до 3 |
|||
| 1. | 
Horacek J. M. Evaluation of serum levels of multiple cytokines and adhesion molecules in patients with newly diagnosed acute lymphoblastic leukemia using biochip array technology [Електронний ресурс] / J. M. Horacek, T. Kupsa, M. Vasatova, L. Jebavy, P. Zak // Experimental oncology. - 2013. - Vol. 35, № 3. - С. 229-230. - Режим доступу: http://nbuv.gov.ua/UJRN/EOL_2013_35_3_16 Aim - evaluation of serum levels of 17 cytokines and 5 adhesion molecules in patients with acute lymphoblastic leukemia (ALL) and in healthy subjects using biochip array technology. This approach allows multi-analytical determination from a single sample. A total of 15 ALL patients and 15 healthy subjects (blood donors) were studied. Serum samples were analyzed by biochip based immunoassays on the Evidence Investigator analyzer. T-tests were used for statistical analysis. Comparing cytokine and adhesion molecule levels in ALL patients and in healthy subject, we found significant increase in serum VCAM-1 (p << 0,000001), ICAM-1 (p << 0,0001), L-selectin (p << 0,0001), IL-8 (p << 0,001), MCP-1 (p << 0,01), and significant decrease (p << 0,01) in serum IL-3 and IL-4. Conclusion: our results indicate that serum levels of specific cytokines and adhesion molecules (VCAM-1, ICAM-1, L-selectin, IL-8, IL-3, IL-4, MCP-1) are significantly altered in patients with newly diagnosed ALL, reflecting activity of the disease. Further investigation is needed to establish if these alterations could be used as a prognostic indicator for ALL. | ||
| 2. |
Horacek J. M. Biochip array technology and evaluation of serum levels of multiple cytokines and adhesion molecules in patients with newly diagnosed acute myeloid leukemia [Електронний ресурс] / J. M. Horacek, T. Kupsa, M. Vasatova, L. Jebavy, P. Zak // Experimental oncology. - 2014. - Vol. 36, № 1. - С. 50-51. - Режим доступу: http://nbuv.gov.ua/UJRN/EOL_2014_36_1_12 Aim - evaluation of serum levels of 17 cytokines and 5 adhesion molecules in patients with newly diagnosed acute myeloid leukemia (AML) and in healthy subjects using biochip array technology. A total of 15 AML patients and 15 healthy subjects (blood donors) were studied. Serum samples were analyzed by biochip based immunoassays on the Evidence Investigator analyzer. This approach allows multi-analytical determination from a single sample. T-tests were used for statistical analysis. In newly diagnosed AML patients, we found significant increase (p << 0,01) in serum VCAM-1, ICAM-1, E-selectin, L-selectin, and significant increase (p << 0,05) in serum IL-6, IL-8. No significant differences were found in the levels of other evaluated cytokines and adhesion molecules. Conclusion: Our results indicate that serum levels of specific cytokines and adhesion molecules (VCAM-1, ICAM-1, E-selectin, L-selectin, IL-6, IL-8) are significantly altered in patients with newly diagnosed AML, showing activity of the disease. Whether these alterations could serve as a prognostic marker for AML is not known. Further studies will be needed to define the potential role of these and additional markers in the risk stratification of AML. | ||
| 3. |
Kupsa T. Baseline serum levels of multiple cytokines and adhesion molecules in patients with acute myeloid leukemia: results of a pivotal trial [Електронний ресурс] / T. Kupsa, M. Vasatova, I. Karesova, P. Zak, J. M. Horacek // Experimental oncology. - 2014. - Vol. 36, № 4. - С. 252-257. - Режим доступу: http://nbuv.gov.ua/UJRN/EOL_2014_36_4_9 Aim - evaluation of serum levels of 17 cytokines and 5 adhesion molecules in patients with newly diagnosed acute myeloid leukemia (AML) using biochip array technology. We searched for links between baseline levels and age, hyperleukocytosis, secondary origin of AML, resistance to induction therapy with cytarabine and daunorubicin and standard risk stratification according to cytogenetics and molecular genetics. We evaluated the sera of 51 consecutive patients. Serum samples were analyzed by biochip based immunoassays on the Evidence Investigator analyzer. T-tests were used for statistical analysis. We found, that higher age is associated with lower levels of interleukin (IL)-12. Patients with secondary disease were older, had higher levels of EGF and IL-7, and lower levels of E-selectin, IL-12 and IL-13. In hyperleukocytosis, the levels of IL-1beta, IL-2, TNF-alpha, VCAM-1, ICAM-1, E-selectin and L-selectin were increased, whereas levels of IFN-gamma and MCP-1 were decreased. In patients who failed to achieve complete remission after induction therapy, we found lower E-selectin and P-selectin levels. High risk patients had lower levels of IFN-gamma. Conclusion: some leukemic cell subpopulations have the ability to produce cytokines that modulate the microenvironment by inducing inflammation. This causes endothelial cells to be activated and overexprcss adhesion molecules. Hyperleukocytosis and secondary origin of the disease are the nuyor factors influencing the cytokine and adhesion molecule profile in newly diagnosed AML patients. | ||
Попередній перегляд: 
Реферативна БД
 |
| Відділ наукової організації електронних інформаційних ресурсів |
 Пам`ятка користувача |